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CLIMB Project Update: Results of primary analysis 05/07/2018

EORTC-ESSO 1409 GITCG: A prospective colorectal liver metastasis database with an integrated quality assurance program (CLIMB): Results of primary analysis

EORTC & ESSO developed an infrastructure for surgical quality assurance (QA) in clinical trials (SURCARE) to advance the surgical research agenda in Europe. The first project is CLIMB, a prospective study to benchmark practices for unresectable or borderline resectable colorectal liver metastasis (CRLM) surgery. The results of the primary analysis has been presented in ASCO Annual Meeting in Chicago last June as a poster. It was also chosen for oral presentation during the the 38th ESSO Congress as part of the Nial O’Higgins Awards Symposium for Best Abstracts.

CLIMB included 14 specialized centers in 9 countries. Primary endpoint was 30 and 90 day surgical complication rate according to Clavien-Dindo Classification. Among 210 patients registered, 126 (60%) who had at least one liver surgery were analyzed. Findings from this study will be used to harmonize standards in MDT evaluation, biomarker testing and imaging for metastatic colorectal cancer in Europe and to develop trials with enhanced QA methods to improve cancer surgery.

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