Go Safe Project

Better understanding of outcomes that matter to older patients

Promoted by ESSO and the surgical task force of SIOG (International Society of Geriatric Oncology), GO SAFE (Geriatric Oncology Surgical Assessment and Functional rEcovery after Surgery) is a new research study that evaluates postoperative functional outcomes and quality of life after cancer surgery in geriatric patients.

Progressive aging of the world population has become one of the most significant challenges for national health care systems. With aging, the incidence and prevalence of cancer increases: it has been estimated that in 2020 more than 60% of all malignancies will occur in patients aged 70-years and older. At the same time, progress in medical knowledge has had a positive impact in clinical practice. In particular, significant improvements in perioperative care with standardized pathways, intraoperative care with minimally invasive surgery, and postoperative care with the introduction of multimodal pain control and enhanced recovery pathways have made oncologic surgery feasible for a larger proportion of patients. Nevertheless, several studies have shown that senior adults affected by cancer are often sub-optimally treated, based on chronological age alone.

The goal of the Geriatric Oncology Surgical Assessment and Functional rEcovery after Surgery (GOSAFE) study was to obtain prospective data on both quality of life (QoL) and functional recovery after surgery.

GOSAFE prospectively collected a baseline multidimensional evaluation before major elective cancer surgery in older patients from 26 international units.

Short−/mid−/long-term surgical outcomes were recorded with quality of life and functional recovery data.

1004 patients were enrolled in a 26-month span.

Demographic data of the study are available from the first publication in the Journal of Geriatric Oncology

Previously unknown PROs and functional recovery data are going to be soon presented from GOSAFE; The study will show that cancer surgery in senior adults is necessary, safe and leads to a restored quality of life and will report about perioperative items that correlate with a worse QoL 3 and 6 months after surgery. These tools should be used along with conversations about goals-of-care and measurement of patients reported outcomes to guide the preoperative decision about whether to pursue surgery, what kind of surgery to pursue, and help direct patients’ expectations.

Final report about QoL and FR are under peer review and will soon be published.

ESSO Industry Partner